Customer Success Stories
The numbers clients hired us for, and where they are published. Client identities stay confidential; two of the results below are patented by the clients who own them.
Client program · STEM™ affinity maturation
1,338×
A client lead taken from 5.9 nM to 4.4 pM
Apparent KD measured in-house by Octet, across the engineered clones. The client patented the result.
Client program · STEM™ on a human Fab
10.8×
Human therapeutic Fab: 5.1 nM → 473 pM
Affinity maturation on a client-supplied human antibody fragment. The client patented the engineered clone.
Published case · humanization + STEM™
2.8×
Infliximab made more potent and more developable
2.8× more potent than infliximab and 4.8× than adalimumab; AC-SINS Δλmax 19.33 → −1.67 nm; >1,800× faster off-rate at pH 5.8.
Published · Antibody Therapeutics 2023
21/21
A neutralizing antibody rebuilt for every variant tested
From 7 of 21 to 21 of 21 SARS-CoV-2 variants neutralized after re-maturation; ≤7 pM KD on BQ.1.1. All eight authors are Abwiz Bio.
Track record · humanization
15/15
Every humanization delivered a usable lead
15 of 15 programs produced a humanized variant retaining at least 80% of parental affinity in the first design pass; 8–12 weeks typical.
Client program · expression rescue
>10×
A functional lead that would not express
More than 10× expression gain while keeping function; 71–91 mg/L achieved in-house.
Have a lead or a target like these?
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What clients say
“With Abwiz, you get a bigger library, so you have more options to pick a good, high affinity antibody.”
Senior Scientist at a biopharmaceutical company
“We chose Abwiz because we wanted something fast, and they're using phage display, so you can really select for the properties that you want”
PRINCIPAL SCIENTIST AT AN IN VITRO DIAGNOSTICS COMPANY
“One of the nice things when you go through Abwiz, is that you own the antibody free and clear. They don't charge you downstream royalties for your later development of a product.”
PRINCIPAL SCIENTIST AT AN IN VITRO DIAGNOSTICS COMPANY
“Abwiz is willing to do a lot of optimization, they really do a lot of work, putting a lot of time on a project. And some other vendors I work with don't want to do anything extra to make our antibody.”